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5 Medical Writing Tips for Novice Writers

5 Medical Writing Tips for Novice Writers

  • Always start with an outline and ensure that all the relevant questions are answered:
    •  What is the research topic and what is its importance?
    •  What is the hypothesis formulation strategy?
    •  What were the expected results and the major findings of the study?
  • Create an IMRAD strategy:
    •  Introduction: Importance of study, what is already known, hypothesis, objectives
    •  Materials and Methods: Materials, subjects, design, procedure used for study
    •  Results: Findings of the study and related to study
    •  Discussion and Conclusions: Discussion of supporting studies , previous literature, limitations, future prospects of study
  • Prepare the draft:
    •  Start with materials and methods
    •  Be specific, clear, concise, and objective in writing results (prepare figure/ table wherever required)
    •  Start with the introduction to attract the reader by highlighting the novelty of the study, followed by discussion
  • Review the draft as a reviewer:
    •  Review the paper thoroughly and revise it
  • Submit the final draft according to journal guidelines
    •  Follow the order: title page; abstract and key words; main text; acknowledgements (optional); conflicts of interest (optional); references; author information; figure legends; tables
    •  Be strict for word limits (total word count/ abstract’s word count)
    • Take care of number of figures and tables to include
    •  Make sure that the reference style in text as well as bibliography is followed

 

THS shares a few tips on medical writing for novice writers. At THS, we provide medical writing assistance to healthcare professionals. Medical writing is a creative way of communication for those who love to write and want to keep abreast with the recent developments in science. While writing a manuscript, try to follow these tips and prepare the manuscript as per the instructions given by a journal. However, its acceptance and publication is not at your will. You may, sometimes, face rejection at initial stages. Revise, edit and modify your paper. Keep practicing. Brush up your writing skills and get ready to type your next manuscript.

#BreastCancerAwarenessMonth

Protect yourself from Breast Cancer

  • Over last ten years or so, breast cancer is the most common cancer in most cities in India, and 2nd most common in the rural areas.
  • Although women are highly prone to breast cancer, men may rarely get it.

Know the risk factors

  • Age: More incidences in India occur in women over the age of 40-50. However, breast cancers in young pre-menopausal women tend to be more aggressive.
  • Family history: Women with close relatives or first-degree female relative (sister, mother, daughter) who’ve been diagnosed with breast cancer or an inherited mutation in the BRCA1 and BRCA2
  • Race and ethnicity: White women are slightly more likely to develop breast cancer than are African-American women, but African-American women are more likely to die of this cancer.
  • Dense breasts due to age, menopausal status, certain medications (including menopausal hormone therapy), pregnancy, and genetics.
  • Exposure to the hormone estrogen:
    • Longer Menstrual periods, i.e., early menarche or late menopause
    • Combined hormone therapy given to women after menopause
    • Parabens and phthalates in cosmetics, hair spray and many other cleaning product fragrances.
  • Previous exposure to radiation for treatment of some malignancy (e.g., lymphoma).
  • Diethylstilbestrol (DES) exposure
  • Environmental pollutants such as organochlorine pesticides.
  • Occupational exposures: Women employed in commercial sterilization facilities (exposure to high levels of ethylene oxide) and the night shift workers (disturbed sleep/wake cycles).
  • Contraceptives: Oral contraceptives (birth control pills) and Depot-medroxyprogesterone acetate, DMPA (injectable progesterone for birth-control).
  • Benign breast conditions: Women diagnosed with certain benign breast conditions might have an increased risk of breast cancer.
  • Lobular carcinoma in situ: Also known as lobular neoplasia, it is an abnormal cellular outgrowth which may become cancerous (invasive) if left untreated for long.
  • Other factors include alcohol-consumption, obesity and lower rates of breast-feeding.

Stay healthy, get screened

A screening plan is planned by the doctor depending upon the unique situation of the patient, if one has been diagnosed with breast cancer.

  • A monthly breast self-exam: Women should know how their breasts normally look and feel and report any breast changes to a health care provider right away.
  • A yearly medical breast exam by a doctor at age 40 and continuing for as long as a woman is in good health
  • Clinical breast exam (CBE) about every 3 years for women in their 20s and 30s and every year for women 40 and over
  • One might have one screening test, such as a mammogram, and then have a different test — an MRI — 6 months later.

In addition to the recommended screening guidelines for women at average risk, a screening plan for a woman with a history of breast cancer may include the above screening tests.

  • For women aged 20-30 years, breast self-exam (BSE) is an option for those starting in their 20s. A breast self-exam is when you check your own breasts for lumps, changes in size or shape of the breast, or any other changes in the breasts or underarm (armpit)
  • For women aged 40–49 years, mammography may save lives, but the benefit for younger women may be less than for older women.
  • For women aged 50–69 years, all women in this age group should have mammograms on a regular basis
  • For women above the age of 70 years, screening mammography is probably beneficial for women aged over 70 years who are in good health and have a life expectancy of about 10 years.

Turacoz Healthcare Solutions as a socially responsible company spreads the word and awareness and looks forward to collaboration or associations with other agencies/companies with similar goals and aspirations. We have a skilled and competent team of medical writers, clinicians, researchers and biostatisticians. Our clients include major pharmaceutical companies, hospitals and healthcare professionals. Our experience has been in supporting publications, creating regulatory documents, conducting observational studies, designing and creating for print and digital marketing as well as customizing sessions on medical writing. 

Turacoz supports #SarcomaAwarenessMonth: Do not loose hope

 “Once you choose hope, anything’s possible.”

Christopher Reeve

Sarcoma, may be defined as “a malignant tumor of connective or other non-epithelial tissue.” It occurs in the connective tissue of the body including fat, blood vessels, nerves, bones, muscles, deep skin tissues, and the cartilage.

Types of Sarcoma

Liposarcoma Most common soft tissue sarcoma. Develops in the deep fatty tissue. They are firm, bumpy, and invade the surrounding tissues invasively
Fibrosarcoma Occur in the arms, legs, or the trunk. Occur around scars, muscles, tissues, tendons, and around the lining of the bone
Dermatofibrosarcoma Protuberans Develops as tumor outgrowths forming outside the skin and are commonly observed on the back or the abdomen. If untreated, the tumor may break through the skin leaving an open wound
Malignant Fibrous Histiocytoma Types include storiform pleomorphic, myxoid malignant fibrous histiocytoma, malignant giant cell tumor of soft parts, and inflammatory malignant fibrous histiocytoma. Usually observed in patients above 50 yr of age and occurs more commonly in men than women.
Synovial Cell Sarcoma Occurs most commonly next to a joint in the arms or legs. This type of sarcoma is very painful and is usually treated with radiation, chemotherapy, or amputation combined with chemotherapy.
Epithelioid Sarcomas Occurs in hand and foot of younger adults. Appears like small nodules. Difficult to treat with surgical intervention and treated with amputation.
Rhabdomyosarcomas Accounts for nearly half of sarcomas in children. Types include embryonal, alveolar, botryoid, and pleomorphic rhabdomyosarcoma.
Leiomyosarcoma and Uterine Sarcoma Occurs in the smooth muscles mainly in the gastrointestinal tract and the uterus. Metastases occurs in half of the patients and is usually treated with total abdominal hysterectomy.
Gastrointestinal Sarcoma Results in the formation of stroma in the stomach and intestines. Treated with Gleeve (a biological agent that retards the activity of gtenes required for the growth of tumor).
Alveolar Soft-Parts Sarcoma Very rare type of sarcoma which usually occurs in female adolescents and young adults. Slow growing tumor found in extremities and metastases into the lungs.
Kaposi’s Sarcoma A condition in which cancerous cells are found underneath the skin or mucous membranes (mouth, nose, or anus). Commonly occurs in older Jewish, Italian, or Mediterranean men, patients receiving organ transplant, and patients with AIDS.

 

The diagnosis of sarcoma is extremely rare worldwide. Often, patients do not experience any pain or discomfort due to the presence of sarcoma which is the most common reason for its late diagnosis. The diagnosis is confirmed after a series of tests including biopsies, computed topography scan (CT-scan), positron emission tomography scan (PET scan), X-ray, magnetic resonance imaging (MRI), ultrasound, and laparoscopic procedure. In most cases, patients have already gone through immense amount of stress until the diagnosis of sarcoma is confirmed. Developing a thorough treatment plan for sarcoma is only possible with a confirmed diagnosis of the condition. The presently available treatments for soft tissue sarcoma include surgery, radiation therapy, chemotherapy, interventional radiology, and targeted therapy.

The National Cancer Institute recommends different treatment options as per the stage of sarcoma.

  • Stage I adult soft tissue sarcoma
    • Surgical removal of the tumor along with radiation therapy either before or after the surgery.
  • Stage II adult soft tissue sarcoma
    • Surgery to remove the tumor; radiation therapy before or after the surgery; radiation therapy or chemotherapy before limb sparing surgery; and high dose radiation therapy for tumors that cannot be removed by surgery
  • Stage III adult soft tissue sarcoma that has spread to the lymph nodes (advanced)
    • Surgery with lymphadenectomy followed by radiation therapy; a clinical trial of surgery followed by chemotherapy; and a clinical trial of regional hyperthermia therapy
  • Stage IV adult soft tissue sarcoma
    • Includes chemotherapy and surgery to remove cancer that has spread to the lungs

 

The duration and intensity of sarcoma therapy can be astonishing and unsettling for patients and their families, and coping with the adverse effects of treatments can be a major and drastic challenge.

The sarcoma center in India “Soft Tissue Tumor Online http://www.histopathology-india.net/SoftTissuePath.htm

There are many NGOs which aides’ new patients and their loved ones to comprehend a sarcoma diagnosis, look for the best care, manage treatment, adapts well and find support.

 

Beat Sarcoma beatsarcoma.org
Cure for Sarcoma http://www.cureforsarcoma.com/
Cynthia Solomon Holmes Foundation http://www.cynthiaholmesfoundation.com/
Dani’s Foundation www.danisfoundation.org
Desmoid Tumor Research Foundation dtrf.org
GIST Support International gistsupport.org
H. Lee Moffitt Cancer Center in Tampa moffitt.org
Kristen Ann Carr Fund www.sarcoma.com
Liddy Shriver Sarcoma Initiative sarcomahelp.org
The Life Raft Group liferaftgroup.org
LMSarcoma Direct Research http://www.lmsdr.org/
Jared Juggernaut http://jaredsjuggernaut.org/
Northwest Sarcoma Foundation nwsarcoma.org
Sarcoma Alliance http://sarcomaalliance.org/
Sarcoma Alliance for Research through Collaboration (SARC) www.sarctrials.org
Sarcoma Foundation of America www.curesarcoma.org

 

 

Diabetes Management and Ramadan: What does ADA say?

Ramadan is a lunar based fasting month for Muslims. Muslims who fast during this time should refrain from eating, drinking, use of oral medications and smoking from predawn to post sunset, with no restrictions on food or fluid intake between sunset and dawn. Muslims with diabetes insist on fasting during the holy month, thus creating challenge for themselves and their health care providers. In this article we enumerated some risk factors associated with diabetic patients and how to manage diabetes in Ramadan, according to the ADA recommendations shared in 2005.

Risk associated with fasting in patients with diabetes.

Hypoglycemia: Reduced food intake is a well-known risk factor for developing hypoglycemia. The effect of fasting during Ramadan on hypoglycemic rates is not well known. But, in a study conducted it was observed that fasting during Ramadan increased the risk of severe hypoglycemia by 4.7 fold in patients with type 1 diabetes and 7.5-fold in patients with type 2 diabetes. In addition, the risk of severe hypoglycemia was more common in patient in whose dosage of oral hypoglycemic agents or insulin was changed as well as those who reported a significant change in their lifestyle.

Hyperglycemia: Glycemic control deteriorated, improved, or showed no change in patients who fasted during Ramadan. A study conducted showed 5 fold increase in the incidence of severe hyperglycemia (required hospitalization) for patients with type 2 diabetes and 3 fold increase in the incidence of severe hyperglycemia with or without ketoacidosis in patients with type 1 diabetes. This can be attributed to excess reduction in medication dose for preventing hypoglycemia. Patients with reported increase in food and/or sugar intake had higher rates of severe hyperglycemia.

Diabetic ketoacidosis: Patients with type 1 diabetes fasting during Ramadan have a greater risk of developing diabetic ketoacidosis, especially if their diabetes is poorly controlled. The risk is increased even further because of excessive reduction of insulin dose as food intake too is relatively reduced during that time.

Dehydration and thrombosis: Fluid intake limitation during the fast if prolonged, leads to dehydration (becomes severe in hot and humid climates and in patients who perform physical labor).

Hyperglycemia causes an osmotic diuresis, adding to the volume and electrolyte depletion. In patients with preexisting autonomic neuropathy orthostatic hypotension may be developed. Syncope, falls, injuries, and bone fractures may occur from hypovolemia and the associated hypotension. Blood viscosity may be increased due to dehydration, which may enhance the risk of thrombosis and stroke.

Managing diabetes in Ramadan

  1. Frequent monitoring of glycaemia: especially important for patients with type 1 & 2 diabetes requiring insulin.
  1. Nutrition: Have a well-balanced diet. Avoid large amount of food rich in carbohydrates and fats at sunset. Foods having complex carbohydrate ((slow digesting foods) should be had as a predawn meal and must be eaten as late as possible before start of daily fast. Fluid intake must be increased during non-fasting hours.
  1. Exercise: Normal physical activity may be maintained. Avoid excessive physical activity, which can lead to higher risk of hypoglycemia, especially during few hours before sunset meal.
  1. Breaking the fast: Fast must be broken if
  • Feeling hypoglycemic (blood glucose of 60 mg/dl). Blood glucose may drop further if treatment is delayed.
  • Blood glucose reaches 70 mg/dl in first few hours after start of sunset and especially if insulin, sulfonylurea drugs, or meglitinide are taken at predawn.
  • Blood glucose exceeds 300 mg/dl.
  • Avoid fasting on sick days
  1. Pre-Ramadan medical assessment: should be undertaken 1–2 months before Ramadan. During this time, appropriate blood studies need to be done and evaluated. Individualized advice must be provided if there is any potential risk to the patient. In addition, necessary changes in diet or medication regimen should be made.
  1. Ramadan-focused structured diabetes education: Healthcare professionals need to be trained to deliver structured diabetes education during Ramadan, which should include:
  • Glucose monitoring importance during fasting and nonfasting hours.
  • When fast should not be done or stopped.
  • Planning of meal if feeling hypoglycemic and dehydrated during long fasting hours.
  • Timing and intensity of physical activity during fasting.
  • Importance of diabetes-related medications and its risk during fasting.
  1. Managing of patients with type 1 diabetes
  • Close monitoring and frequent insulin adjustments are essential for avoiding hypo- or hyperglycemia in patients with type 1 diabetes.
  • Continuous subcutaneous insulin infusion (pump) management can also be done, but is substantially expensive.
  1. Managing of patients with type 2 diabetes:
  2. Diet-controlled patients : there is a potential risk for occurrence of postprandial hyperglycemia in type 2 diabetic patients. In such cases:
  • Spreading calories over 2 to 3 smaller meals during the nonfasting interval may help in preventing excessive postprandial hyperglycemia.
  • Intensity and timing of physical activity may be modified e.g.,2 h after the sunset meal.
  1. Patients treated with oral agents: choice of oral agents should be individualized.
  2. Patients on metformin : have limited possibility of severe hypoglycemia and may fast safely. However, dose timing should be modified so as to provide 2/3rd total daily dose with the sunset meal and the 1/3rd before the predawn meal.
  3. Use of sulfonylurea’s: is unsuitable for use during Ramadan as it posses inherent risk of hypoglycemia. Use of these drugs should be done with individualized with caution. Chlorpropamide use is contraindicated during Ramadan due to risk of prolonged and unpredictable hypoglycemia.
  4. Short-acting insulin secretagogues: could be taken two times daily before the sunset and predawn meals.
  5. Incretin-based therapy: drugs such as Exenatide in particular, can be given before meals to minimize appetite and promote weight loss. Due to its short half-life of 2 hrs, it’s not associated a substantial effect on fasting glucose.
  6. Patients treated with insulin: To maintain necessary levels of basal insulin and preventing fasting hyperglycemia, use of intermediate- or long acting insulin preparations and short acting insulin need to be given before meals. Also, injecting long-acting or intermediate-acting insulin can give adequate coverage in few patients as long as dosage is appropriately individualized.
  7. Insulin Pumps: Frequent glucose monitoring is needed due to failure of the pump infusion site can result in severe deterioration in control over a few hours. Patients with type 1 diabetes must be fully educated and facile about the use of an insulin pump. Before Ramadan, they should receive adequate training and education with respect to self management and insulin dose adjustment. Also, how to adjust their infusion rates as per results of frequent home blood glucose monitoring must be taught.
  1. Pregnancy and fasting during Ramadan: Women with presentational or gestational diabetes are at increasingly high risk and should be strongly advised not to fast during Ramadan. However, if they insist to fast, then special attention must be given to their care. Pre-Ramadan evaluation of their medical condition should be carried out that includes, preconception care with emphasis on achieving near-normal blood glucose and A1C values, counseling regarding maternal and fetal complications associated with poor glycemic control, self management education skills. These patients should be managed in high-risk clinics having obstetrician, diabelogists, a nutritionist, and diabetes nurse educators. Appropriate diet and intensive insulin therapy should be given to pregnant patients. In addition, frequent monitoring and insulin dose adjustment is necessary.
  1. Management of hypertension and dyslipidemia: Dehydration, volume depletion, and tendency towards hypotension may occur with fasting during Ramadan, especially if fasting is extended for long and is also linked with increased perspiration. Therefore, dose and/or type of anti-hypertensive medications should be adjusted for preventing hypotension. Further, proper counseling need to be given and agents previously given for managing elevated cholesterol and triglycerides should be continued.

Key messages

Fasting by diabetic patients should be done after prolonged discussion with their health care provider so as to discuss the risks involved. Patients, who insist on fasting in Ramadan, must undergo pre-Ramadan assessment and receive appropriate education and instructions related to physical activity, meal planning, glucose monitoring, and dosage and timing of medications. Newer pharmacological agents have lesser hypoglycemic potential and can be specifically useful during Ramadan. Similarly, insulin pump therapy can give greater safety in Ramadan setting.

Read more at

Al-Arouj M,Assaad-Khalil S, Buse J, Fahdil I, Fahmy M, Hafez S, et.al, Recommendations for Management of Diabetes During Ramadan. Diabetes Care; 2010.33 (8), 1895-1902.

July is #SarcomaAwarenessMonth: Come Spread the Word

Sarcomas are the tumors originating from mesenchyme and contribute to about  20% of all pediatric solid malignant cancers and less than 1% of all adult solid malignant cancers. Sarcoma develops in connective tissue-cells that connect or support other types of tissue in the body. These forms of tumor are most common in normal connective tissues of bones, muscles, tendons, cartilage, nerves, fat, blood vessels of arms and legs, but they can occur anywhere.

What is Sarcoma awareness month?

The majority of patients present in advanced stage of diseases mainly due to ignorance of disease as well as apprehension and fear of surgery. The economic constraints also delay the detection and management. The awareness for the disease is far less and hence the importance of July as the ‘Sarcoma awareness month’, giving a right opportunity to learn more about the disease, spreading awareness to everyone and making difference in lives of patients fighting sarcoma.

Types of Sarcomas

Though sarcomas are more than 50 types, they can be classified into two main kinds: soft tissue sarcoma and bone sarcoma or osteosarcoma. The sarcomas are further sub-classified into based on type of presumed cell of origin found in the tumor. All of these types have certain microscopic characteristics and similar symptoms.

Who is affected?

Sarcomas develop in both children and adults. In children of less than 20 years of age, 15% (approximately) of diagnosed cancer are sarcomas. In adults, about 1 out of 100 adult cancer cases are soft tissue sarcomas. Osteosarcomas are still rare. Treatment of sarcomas is by surgery for tumor removal.

Risk factors

  • Most sarcomas have no known cause. Following factors can contribute to risk factors for developing sarcomas:
  • Previous radiation therapy for cancer.
  • Genetic disorder such as neurofibromatosis type I, Gardner syndrome, Werner syndrome, nevoid basal cell carcinoma syndrome, tuberous sclerosis, Li-Fraumeni syndrome or retinoblastoma.
  • Exposure to chemicals such as vinyl chloride monomer used for making plastics.

Symptoms

There may be no signs and symptoms initially or these symptoms may be caused by medical condition, which is not cancer. Soft tissue sarcomas are usually hard to be spot as they grow anywhere in the body.

First signs of sarcoma in an arm, leg, or torso could be painless lump or swelling. These lumps may get bigger as time progresses and might press against nerve or muscles making one uncomfortable or give breathing trouble or both. Unfortunately, there are no tests that can detect these tumors before symptoms occur.

Most often lumps may not be sarcomas and soft-tissue lumps are lipomas, which are made of fat cells and not cancerous. Sarcomas in abdomen may not have any symptoms, or may cause pain or give sense of fullness.

Symptoms or osteosarcoma are more evident, including:

  • On and off pain in the affected bone, that may be worse at night.
  • Swelling that often starts weeks after the pain.
  • Limp, if sarcoma is present in the leg.

Diagnosis

Biopsy: is the only way to find for certain if tumor is a sarcoma.

If biopsy is not possible, other tests may be suggested that can be useful for diagnosis. Imaging tests can be used to find out if cancer has metastasized.

Before choosing diagnostic test following factors may be considered:

  1. Age and medical condition
  2. Type of cancer suspected
  3. Severity of symptoms
  4. Earlier test results

Imaging tests used before or after biopsy for determining location and extent of tumor includes:

  • Ultrasound
  • Chest X-ray
  • CT or CAT (computed axial tomography)
  • MRI (magnetic resonance imaging) scans
  • PET (positron emission tomography) scans
  • Bone scan – for osteosarcoma

Treatments

If sarcoma is diagnosed, treatment may depend of several factors that include:

  1. Location and type of sarcoma.
  2. Spread of cancer.
  3. Impact on body.
  4. Health in general.

Depending on above parameters, treatment for sarcoma is customized as per the needs and may include one or more of the following:

Surgery: is done to remove tumor out of the body. In osteosarcoma, only cancer cells can be removed and arm or leg won’t be amputed.

Chemotherapy: may be used as main treatment of sarcoma or with surgery or radiation. Combination of two or more chemotherapy drugs may be used. In some cases, limb profusion, a special way for giving more focused dose of chemotherapy may be done.

Radiation Therapy: not used as main sarcoma treatment, but can be used before surgery for shrinking the tumor or after surgery for destroying remaining cancer cells.

Proton Therapy: gives high doses of radiation directly to tumor site and spares nearby healthy tissue and vital organs.

Post-Treatment plan

Talking with health care provider is essential to develop a follow-up care plan. The plan may include:

  • Regular physical examinations and/or medical tests to monitor the recovery and possible tumor recurrence if any.
  • Learning ways to prevent or manage side effects, if undergone radiation therapy for treating sarcomas where region of the body may be at risk for limb swelling (lymphedema), fracture of the thigh or leg bones, poor joint mobility and hardness of the soft tissues (fibrosis).
  • Rehabilitation program (such as range-of-motion exercises, strengthening exercises, and lymphedema reduction exercise) post surgery or radiation therapy for regaining or maintaining limb function.

Turacoz Healthcare Solutions  takes steps in creating awareness and communicating to the society  information on disease-diagnosis, prevention, management and complications because we believe in

You may never know what results come from your action, but it you do nothing there will be no results.

#InternationalYogaDay2015: India is the Global Spiritual Capital

Yoga has been an integral part of India since Indus Saraswati civilization for about 5000 years now. With time the nomenclature has changed with modifications in the practise but the benefit is still the same. Today’s fast paced life with challenges from all quarters requires us to practice a discipline which is beyond achieving a physical goal. The need of the hour is a comprehensive health goal which focuses on physical, mental and spiritual health together.

Types of Yoga

Bhagawad Gita introduces 3 prominent types of Yoga:

  1. Karma yoga: Yoga of action
  2. Bhakti yoga: Yoga of devotion
  3. Jnana yoga: Yoga of knowledge

The Eight-Limbed Yoga or “Ashtanga Yoga” of Patanjali’s writing are as follows:

  1. Yama or the five abstentions
  2. Niyama or the five observances
  3. Asana which literally means seated position used for medidation
  4. Pranayama is to restrain or stop breathing
  5. Pratyahara is the withdrawal of sense organs from external objects
  6. Dharana is concentrating on one object
  7. Dhyana is meditation
  8. Samadhi is the merging consciousness with the object of meditation

There is something for every individual in yoga, all age groups including children and youth, patients with chronic illness like diabetes, hypertension, asthma, obesity etc.

On this First International Yoga Day, the atmosphere is positive and highly charged and let’s make yoga a part of our lives.